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The loss of estrogens regulatory influence on hepatic and systemic metabolism is recognized as a major factor contributing to the surge in cardiovascular morbidity and mortality among postmenopausal women 18,19,20
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The adverse reactions that occurred in placebo-controlled clinical trials in at least 2% of patients treated with amlodipine and valsartan but at a higher incidence in amlodipine/valsartan patients (n=1437) than placebo (n=337) included peripheral edema (5.4% vs 3%), nasopharyngitis (4.3% vs 1.8%), upper respiratory tract infection (2.9% vs 2.1%) and dizziness (2.1% vs 0.9%)
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